Read about Curt's amazing research in phages and pathogens.
It was January 19, 2017 when my friend Garret pitched the idea: “What if we used phages to cure disease?” We were sitting in the computer lab discussing what the next “big idea” could be in
science—something UCAS nerds often do on a Friday afternoon.
Since then, I’ve been involved in virus hunting, from bacteriophages to dangerous pathogens with pandemic potential. I remember back in 2018 giving a midterm presentation in Ms. Hay’s (now Mrs. Hay-Laubaugh’s) career exploration class about my future career in phage therapy. I told my classmates that one day I would work with scientists across the world to advance phage research and save lives. Today, I am on track towards that vision.
After graduating from UCAS, I got to be the first intern at the first phage therapy center in North America, UC San Diego’s IPATH, or the Center for Innovative Phage Applications and Therapeutics. Since its inception, other phage therapy centers have been established in India, Europe, and Australia, most notably in the UK after a Parliament hearing on “the antimicrobial potential of bacteriophages.” The World Economic Forum recently listed “designer phages” as one of the top ten emerging technologies of 2023, among innovations like flexible batteries and generative AI.
Since my introduction to phages at UCAS, I have been involved with colleagues from across the globe on advancing phage therapy as an alternative solution in the antibiotic resistance crisis. Phage therapy is now a hot topic among many groups, including biotech, agriculture, government, health care, and academia. One time, as a student at BYU, I received an email about a patient who was on the verge of death from a multidrug-resistant infection—a sea turtle named Shelly. I connected BYU’s phage labs with the phage therapy center and Yale University, and we were able to save Shelly’s life. This bench-to-bedside approach inspired other undergraduate students to get involved in phage research.
Since 2020, my interests have taken a turn from studying helpful viruses to understanding harmful ones. I worked on Covid-19 research and got to observe consortiums from government, academia, and philanthropy on ways to combat the pandemic. One of the most potent ways to combat future pandemic threats is through education. During the Covid-19 crisis, I joined a group at the Broad Institute of MIT and Harvard who are developing a new discipline called outbreak science. As you and many UCAS students know, we are iterating our program Operation Outbreak to safely simulate viral outbreaks in a classroom in order to teach via experiential learning. Our team at the Broad is writing the first textbook, Outbreak Science, which spans virtually every facet of an outbreak, from pathogens to politics.
In two months, I will graduate with my Bachelor’s degree at BYU, and the world is wide open for more virus hunting. Currently I am an intern at King Chulalongkorn Memorial Hospital in Bangkok at the Thai Red Cross Emerging Infectious Disease Clinical Centre. Thailand fared well during the early stages of Covid, and I am meeting with leaders from the Thai government, healthcare, and academics to learn why. Particularly, I am here to learn Thai culture and scholarship, and to foster relationships between researchers who study outbreak science. Fascinated by books like The Hot Zone by Richard Preston and Outbreak Culture by Pardis Sabeti and Lara Salahi, I get to learn something new each day about the daunting nature of pandemic prevention, preparedness, and response.
For my Ph.D. program, I plan to do surveillance research of Arenaviruses (e.g., Lassa virus, a deadly hemorrhagic pathogen endemic in West Africa) in animals and humans in Thailand. This will be through scientists at U.S. NIH, Oxford University, and Mahidol University in Thailand.
Here are some good sources for students interested in phage therapy:
● IPATH: http://ipath.ucsd.edu/
● Phage Directory: https://phage.directory/
● The Perfect Predator: http://theperfectpredator.com/
● The Good Virus:
https://www.amazon.com/Good-Virus-Amazing-Forgotten-Promise/dp/1324050837
Here are some good sources for students interested in outbreak science:
● Crash Course Outbreak Science:
https://www.youtube.com/playlist?list=PL8dPuuaLjXtPkACD-BkU-oM6PUotjdCEk
● Operation Outbreak: https://operationoutbreak.org/
● Epidemic Tracker: https://www.epidemictracker.com/
● Prevent Epidemics: https://preventepidemics.org/
● Predicting Pandemics: https://nationalzoo.si.edu/news/predicting-next-pandemic
Curtis Hoffman